Evaluation of the effect of pentoxifylline on sleep-deprivation induced memory impairment

Journal Article

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Hippocampus

Sep

812

819

CI: Copyright (c) 2013; JID: 9108167; 0 (Phosphodiesterase Inhibitors); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione); SD6QCT3TSU (Pentoxifylline); OTO: NOTNLM; 2013/04/05 [accep

United States

1098-1063; 1050-9631

PMID: 23592546

eng

Journal Article; Research Support, Non-U.S. Gov't; IM

10.1002/hipo.22135 [doi]

Unknown(0)

23592546

In this study, we examined the ability of Pentoxifylline (PTX) to prevent sleep deprivation induced memory impairment probably through decreasing oxidative stress. Sleep deprivation was chronically induced 8 h/day for 6 weeks in rats using modified multiple platform model. Concurrently, PTX (100 mg/kg) was administered to animals on daily basis. After 6 weeks of treatment, behavioral studies were conducted to test the spatial learning and memory using the Radial Arm Water Maze. Additionally, the hippocampus was dissected; and levels/activities of antioxidant defense biomarkers glutathione reduced (GSH), glutathione oxidized (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPx), catalase, and superoxide dismutase (SOD), were assessed. The results show that chronic sleep deprivation impaired short- and long-term memories, which was prevented by chronic treatment with PTX. Additionally, PTX normalized sleep deprivation-induced reduction in the hippocampus GSH/GSSG ratio (P

Wiley Periodicals, Inc

Alzoubi,K.H., Khabour,O.F., Tashtoush,N.H., Al-Azzam,S.I., Mhaidat,N.M.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

20130522

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=23592546

2013