Effect of nonsurgical periodontal therapy verses oral hygiene instructions on type 2 diabetes subjects with chronic periodontitis: a randomised clinical trial

Journal Article

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BMC oral health

BMC Oral Health.

25-Jun

6831-14-79

LR: 20150805; ClinicalTrials.gov/NCT01951547; JID: 101088684; 0 (Anti-Infective Agents, Local); 0 (Hemoglobin A, Glycosylated); 0 (Mouthwashes); 9007-41-4 (C-Reactive Protein); R4KO0DY52L (Chlorhexidine); OID: NLM: PMC4082680; 2014/03/12 [received]; 2014/

England

1472-6831; 1472-6831

PMID: 24965218

eng

Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; D; IM

10.1186/1472-6831-14-79 [doi]

Unknown(0)

24965218

BACKGROUND: 40 subjects with type 2 diabetes and moderate to severe CP were randomly distributed to groups receiving either NSPT or OHI. Periodontal parameters, glycosylated haemoglobin (HbA1c) and high-sensitivity C-reactive protein (hs-CRP) were evaluated at baseline, 2- and 3-months intervals. METHODS: 40 subjects with type 2 diabetes and moderate to severe CP were randomly distributed to groups receiving either NSPT or OHI. Periodontal parameters, glycosylated haemoglobin (HbA1c) and high-sensitivity C-reactive protein (hs-CRP) were evaluated at baseline, 2- and 3-months intervals. RESULTS: 15 subjects from NSPT group and 17 from OHI group completed the study. The difference in plaque index (PI) between NSPT and OHI groups were significant at 2 months recall (p = 0.013). There was no significant difference between NSPT and OHI group for all other clinical periodontal parameters, HbA1c and CRP levels. At 3 months post-therapy, periodontal parameters improved significantly in both groups with sites with probing pocket depth (PPD) /= 50% reduction in PPD showed significant reductions of HbA1c and hs-CRP levels (p = 0.004 and p = 0.012). CONCLUSION: NSPT significantly reduced PI at 2 months post-therapy as compared to OHI. Both NSPT and OHI demonstrated improvements in other clinical parameters as well as HbA1c and CRP levels. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01951547.

Raman,R.P., Taiyeb-Ali,T.B., Chan,S.P., Chinna,K., Vaithilingam,R.D.

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. rathna@um.edu.my.

20140625

PMC4082680

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=24965218

2014