Journal Article

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Virchows Archiv : an international journal of pathology

Virchows Arch.

Apr

464

4

409

417

JID: 9423843; 2013/11/05 [received]; 2014/01/27 [accepted]; 2014/01/10 [revised]; 2014/02/18 [aheadofprint]; ppublish

Germany

1432-2307; 0945-6317

PMID: 24535701

eng

Journal Article; Multicenter Study; IM

10.1007/s00428-014-1550-5 [doi]

Unknown(0)

24535701

Multilayered epithelium is defined as hybrid epithelium with characteristics of both squamous and columnar epithelia. Our aim was to evaluate the clinicopathological significance of the lesion by relating its presence to various histological and clinical and/or endoscopic features indicating gastroesophageal reflux disease (GERD). A total of 1,071 individuals participated in a prospective cross-sectional study (576 females and 495 males; median age 53 years). Biopsy material was systematically sampled from the gastroesophageal junction. The histological diagnosis of esophagitis was made according to the Esohisto consensus guidelines. The endoscopic diagnosis of esophagitis was made according to the modified Los Angeles classification and the diagnosis of Barrett's esophagus according to Prague's C & M criteria, respectively. Multilayered epithelium was identified in 103 (9.6 %) individuals, frequently within or adjacent to the ducts of esophageal glands. Its presence was associated with increasing age (p

Langner,C., Wolf,E.M., Plieschnegger,W., Geppert,M., Wigginghaus,B., Hoss,G.M., Eherer,A., Schneider,N.I., Rehak,P., Vieth,M.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria, cord.langner@medunigraz.at.

20140218

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=24535701

2014