Smoking Topography Characteristics of Very Low Nicotine Content Cigarettes, With and Without Nicotine Replacement, in Smokers With Schizophrenia and Controls

Journal Article

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Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Nicotine Tob.Res.

19-Mar

LR: 20160812; CI: (c) The Author 2016; GR: K01 CA189300/CA/NCI NIH HHS/United States; GR: P50 DA036114/DA/NIDA NIH HHS/United States; JID: 9815751; PMCR: 2017/09/01 00:00; 2015/12/08 [received]; 2016/03/09 [accepted]; 2016/03/19 [aheadofprint]; aheadofpri

1469-994X; 1462-2203

PMID: 26995794

ENG

JOURNAL ARTICLE

ntw089 [pii]

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26995794

INTRODUCTION: Reducing the nicotine content of cigarettes to a minimally addictive level has been proposed as a regulatory strategy for reducing tobacco dependence. However, smokers with schizophrenia (SS) may be prone to changing their smoking topography in efforts to compensate for the reduction in nicotine content. The aims of this study were to compare smoking topography characteristics of usual-brand and very low nicotine content (VLNC) cigarettes in SS and control smokers without psychiatric illness (CS), and to determine whether nicotine replacement reversed any changes in topography produced by VLNC cigarettes. METHODS: Using a within-subjects, counter-balanced design, SS (n = 27) and CS (n = 23) smoked usual brand cigarettes, VLNC cigarettes while wearing placebo patches (VLNC + PLA), or VLNC cigarettes while wearing transdermal nicotine patches totaling 42mg (VLNC + NIC) during 5-hour ad libitum smoking sessions. Cigarettes were smoked through topography measurement devices. RESULTS: Across conditions, SS smoked more puffs per session and per cigarette, had higher cigarette volumes, and had shorter inter-puff intervals than CS (Ps

. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco

Tidey,J.W., Cassidy,R.N., Miller,M.E.

Center for Alcohol and Addiction Studies, Brown University, Providence, RI jennifer_tidey@brown.edu.; Center for Alcohol and Addiction Studies, Brown University, Providence, RI.; Center for Alcohol and Addiction Studies, Brown University, Providence, RI.

20160319

PMC4978982

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=26995794

2016