The effect of aging on bone mineral metabolism and bone mass in Native American women

Journal Article

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Journal of the American Geriatrics Society

J.Am.Geriatr.Soc.

Nov

1418

1422

LR: 20131121; GR: 5R01-AG-10436/AG/NIA NIH HHS/United States; JID: 7503062; 104982-03-8 (Osteocalcin); P6YZ13C99Q (Calcifediol); ppublish

UNITED STATES

0002-8614; 0002-8614

PMID: 9809765

eng

Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; IM; S

Unknown(0)

9809765

OBJECTIVE: To examine the effect of age on mineral metabolism and bone mineral density (BMD) of the hip and spine in Native American women. DESIGN: A cross-sectional study. SETTING: The Sac and Fox Nation in rural Oklahoma MEASUREMENTS: Serum measurements were made of 25 hydroxyvitamin D (25OHD), osteocalcin, and immunoreactive parathyroid hormone. Bone mineral density of the hip and spine was assessed by dual energy X-ray absorptiometry. PARTICIPANTS: A total of 77 Native American women aged 19 to 85 years. RESULTS: Serum 25 hydroxyvitamin D was related inversely to age (r = -0.32; P or = -0.48, P or = 0.41, P < .005) were independent determinants of both femoral and lumbar BMD. Serum 25OHD was a significant independent determinant of both lumbar (r = .26, P < .05) and femoral (r = .41, P < .01) BMD. Age, BMI, and serum 25OHD together accounted for 70% of the variance in BMD at these sites. The use of t scores indicated femoral bone density was higher (P < .05) in premenopausal Native American women, and lower (P < 0.05) in postmenopausal subjects, compared with white women. CONCLUSIONS: In Native American women, there is a reduction in bone density and a sustained increase in bone turnover postmenopausally. BMI and serum 25OHD are significant determinants of BMD. Peak BMD may be higher, and the postmenopausal rate of bone loss greater, than that in white women.

Adult, Aged, Aged, 80 and over, Aging/physiology, Bone Density/physiology, Calcifediol/blood, Cross-Sectional Studies, European Continental Ancestry Group, Female, Femur/metabolism/radionuclide imaging, Humans, Indians, North American, Lumbar Vertebrae/metabolism/radionuclide imaging, Menopause/physiology, Middle Aged, Oklahoma, Osteocalcin/blood, Osteoporosis/ethnology/metabolism/radionuclide imaging

Perry,H. M.,3rd, Bernard,M., Horowitz,M., Miller,D. K., Fleming,S., Baker,M. Z., Flaherty,J., Purushothaman,R., Hajjar,R., Kaiser,F. E., Patrick,P., Morley,J. E.

GRECC, St. Louis VA Medical Center, Jefferson Barracks, St. Louis University Medical School, Missouri, USA.

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=9809765

1998