Risk factors associated with Barrett's epithelial dysplasia

Journal Article

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World journal of gastroenterology

World J.Gastroenterol.

21-Apr

4353

4361

LR: 20151022; JID: 100883448; 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53); OID: NLM: PMC3989971; OTO: NOTNLM; 2013/09/05 [received]; 2013/10/27 [revised]; 2013/11/18 [accepted]; ppublish

China

2219-2840; 1007-9327

PMID: 24764673

eng

Journal Article; IM

10.3748/wjg.v20.i15.4353 [doi]

Unknown(0)

24764673

AIM: To elucidate risk factors associated with dysplasia of short-segment Barrett's esophagus (BE). METHODS: A total of 151 BE patients who underwent endoscopic examination from 2004 to 2008 in Aoyama Hospital, Tokyo Women's Medical University, Japan and whose diagnosis was confirmed from biopsy specimens were enrolled in the study. BE was diagnosed based on endoscopic findings of gastric-appearing mucosa or apparent columnar-lined esophagus proximal to the esophagogastric junction. Dysplasia was classified into three grades - mild, moderate and severe - according to the guidelines of the Vienna Classification System for gastrointestinal epithelial neoplasia. Anthropometric and biochemical data were analyzed to identify risk factors for BE dysplasia. The prevalence of Helicobacter pylori (H. pylori) infection and the expression of p53 by immunohistological staining were also investigated. RESULTS: Histological examination classified patients into three types: specialized columnar epithelium (SCE) (n = 65); junctional (n = 38); and gastric fundic (n = 48). The incidence of dysplasia or adenocarcinoma from BE of the SCE type was significantly higher than that of the other two types (P

Fujita,M., Nakamura,Y., Kasashima,S., Furukawa,M., Misaka,R., Nagahara,H.

Mikiko Fujita, Yuri Nakamura, Saeko Kasashima, Maiko Furukawa, Ryoichi Misaka, Hikaru Nagahara, Department of Gastroenterology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo 1070061, Japan.; Mikiko Fujita, Yuri Nakamura, Saeko Kasashima, Maiko

PMC3989971

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=24764673

2014