Journal Article

Print(0)

Indian Journal of Medical Research

Indian J.Med.Res.

1997/

106

NOV.

475

480

0971-5916

Unknown(0)

The present study was envisaged to assess the state of oxidative metabolism of neutrophils, recovered from smokers (cigarette, beedi, hookah and mixed products) and non-smokers. Superoxide anion (O2̇-) production was significantly higher in neutrophils from all groups of smokers (P < 0.001). Total leukocyte count (TLC) was significantly more in symptomatic subjects among the cigarette, hookah and mixed smokers (P < 0.05). Total neutrophil count (TNC) was significantly higher in symptomatic than asymptomatic subjects of hookah and mixed smoking groups (P < 0.05). In the pathogenesis of chronic obstructive pulmonary disease (COPD) in tobacco smokers, the role of leukocytosis, increased neutrophil sequestration into the lung, increased neutrophil toxic oxygen species including superoxide release in the lung may cause direct injury to lung tissues.

reactive oxygen metabolite, superoxide, adult, aerobic metabolism, aged, article, blood, chronic obstructive lung disease, smoking, controlled study, female, human, leukocyte count, leukocytosis, lung injury, lung sequestration, major clinical study, male, neutrophil, oxygen poisoning, pathogenesis, smoking habit, statistical analysis, symptom, tobacco

Embase; MEDLINE

Embase

Sharma,R. N., Deva,C., Behera,D., Khanduja,K. L.

Khanduja, K.L., Postgraduate Institute, Medical Education and Research, Chandigarh 160012, India

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=

1997