Periodontal conditions of individuals with Sjogren's syndrome

Journal Article

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Journal of periodontology

J.Periodontol.

Mar

429

435

JID: 8000345; 0 (Interleukin-1beta); EC 3.4.21.36 (Pancreatic Elastase); ppublish

United States

0022-3492; 0022-3492

PMID: 19254127

eng

Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; D; IM

10.1902/jop.2009.080350 [doi]

Unknown(0)

19254127

BACKGROUND: Sjogren's syndrome (SjS) is a systemic autoimmune disease that might lead to hyposalivation and negatively affect the oral environment. The evidence with regard to the periodontal conditions in this group of subjects is still controversial. This study aimed to evaluate the periodontal clinical conditions and inflammatory markers in gingival crevicular fluid (GCF) from patients with primary Sjogren's syndrome (SjS [P]) or secondary Sjogren's syndrome (SjS [S]) compared to a control group. METHODS: Nineteen individuals with SjS (11 SjS [P] and eight SjS [S]) and 19 controls, matched for gender, age, and tobacco exposure, were selected from two private clinics and a hospital. The groups were compared for stimulated whole saliva (SWS) flow rate, plaque index (PI), gingival index (GI), probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), and total amount of interleukin (IL)-1beta and total elastase activity in the GCF. Generalized estimating equations were used for data analysis. RESULTS: Individuals with SjS had a significantly lower SWS flow rate and higher mean PI, GI, PD, CAL, and BOP than controls. After adjustment for plaque, GI remained significantly higher in patients with SjS. Patients with SjS (S) had significantly higher mean CAL and PD than patients with SjS (P), and CAL and BOP remained significantly higher in this subgroup after adjustment. No differences were observed with regard to the GCF inflammatory markers. After adjusting for PD, subjects with SjS (P) showed lower levels of IL-1beta compared to controls. CONCLUSION: SjS seemed to negatively affect the periodontal condition because gingival inflammation was more evident in the individuals with SjS, particularly those with SjS (S).

Autoimmune Diseases/immunology, Case-Control Studies, Dental Plaque Index, Female, Gingival Crevicular Fluid/chemistry, Gingival Hemorrhage/etiology/immunology, Gingivitis/etiology/immunology, Humans, Interleukin-1beta/analysis, Male, Middle Aged, Pancreatic Elastase/analysis, Periodontal Attachment Loss/etiology/immunology, Periodontal Diseases/etiology/immunology, Periodontal Index, Periodontal Pocket/etiology/immunology, Saliva/immunology/secretion, Secretory Rate/physiology, Sjogren's Syndrome/complications/drug therapy/immunology, Smoking

Antoniazzi,R. P., Miranda,L. A., Zanatta,F. B., Islabao,A. G., Gustafsson,A., Chiapinotto,G. A., Oppermann,R. V.

Postgraduate Program in Dentistry, Brazilian Lutheran University, Canoas, RS, Brazil. raquelantoniazzi@hotmail.com

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=19254127

2009