Journal Article

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Hippocampus

Hippocampus

Sep

23

9

812

819

CI: Copyright (c) 2013; JID: 9108167; 0 (Phosphodiesterase Inhibitors); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione); SD6QCT3TSU (Pentoxifylline); OTO: NOTNLM; 2013/04/05 [accep

United States

1098-1063; 1050-9631

PMID: 23592546

eng

Journal Article; Research Support, Non-U.S. Gov't; IM

10.1002/hipo.22135 [doi]

Unknown(0)

23592546

In this study, we examined the ability of Pentoxifylline (PTX) to prevent sleep deprivation induced memory impairment probably through decreasing oxidative stress. Sleep deprivation was chronically induced 8 h/day for 6 weeks in rats using modified multiple platform model. Concurrently, PTX (100 mg/kg) was administered to animals on daily basis. After 6 weeks of treatment, behavioral studies were conducted to test the spatial learning and memory using the Radial Arm Water Maze. Additionally, the hippocampus was dissected; and levels/activities of antioxidant defense biomarkers glutathione reduced (GSH), glutathione oxidized (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPx), catalase, and superoxide dismutase (SOD), were assessed. The results show that chronic sleep deprivation impaired short- and long-term memories, which was prevented by chronic treatment with PTX. Additionally, PTX normalized sleep deprivation-induced reduction in the hippocampus GSH/GSSG ratio (P 0.05), and activities of GPx, catalase, and SOD (P 0.05). In conclusion, chronic sleep deprivation induces memory impairment, and treatment with PTX prevented this impairment probably through normalizing antioxidant mechanisms in the hippocampus.

Wiley Periodicals, Inc

Alzoubi,K.H., Khabour,O.F., Tashtoush,N.H., Al-Azzam,S.I., Mhaidat,N.M.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

20130522

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=23592546

2013