Journal Article

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PloS one

PLoS One

19-May

9

5

e97805

LR: 20150805; GR: APP1028372/PHS HHS/United States; GR: P30 ES023515/ES/NIEHS NIH HHS/United States; GR: P42 ES016454/ES/NIEHS NIH HHS/United States; GR: P42ES00000/ES/NIEHS NIH HHS/United States; GR: P42ES05947/ES/NIEHS NIH HHS/United States; GR: R00 ES0

United States

1932-6203; 1932-6203

PMID: 24841926

eng

Journal Article; Research Support, N.I.H., Extramural; IM

10.1371/journal.pone.0097805 [doi]

Unknown(0)

24841926

The aim of this study was to assess the validity of micro-spatial dentine lead (Pb) levels as a biomarker for accurately estimating exposure timing over the prenatal and early childhood periods and long-term cumulative exposure to Pb. In a prospective pregnancy cohort sub-sample of 85 subjects, we compared dentine Pb levels measured using laser ablation-inductively coupled plasma mass spectrometry with Pb concentrations in maternal blood collected in the second and third trimesters, maternal bone, umbilical cord blood, and childhood serial blood samples collected from the ages of 3 months to >/=6 years. We found that Pb levels (as 208Pb:43Ca) in dentine formed at birth were significantly associated with cord blood Pb (Spearman rho = 0.69; n = 27; p

Arora,M., Austin,C., Sarrafpour,B., Hernandez-Avila,M., Hu,H., Wright,R.O., Tellez-Rojo,M.M.

Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Faculty of Dentistry, University of Sydney, Sydney, Australia.; Department of Preventive Medicine, Icahn School of Medicine at Mount

20140519

PMC4026445

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=24841926

2014