Concentrations of the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in sidestream cigarette smoke increase after release into indoor air: results from unpublished tobacco industry research

Journal Article

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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Cancer Epidemiol.Biomarkers Prev.

Aug

1547

1553

LR: 20151119; GR: CA-87472/CA/NCI NIH HHS/United States; JID: 9200608; 0 (Air Pollutants); 0 (Carcinogens); 0 (Nitrosamines); 0 (Tobacco Smoke Pollution); 31C4KY9ESH (Nitric Oxide); 64091-91-4 (4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone); 6M3C89Z

United States

1055-9965; 1055-9965

PMID: 17684127

eng

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM

16/8/1547 [pii]

Unknown(0)

17684127

Research has shown that the toxicity of sidestream cigarette smoke, the primary constituent of secondhand smoke, increases over time. To find potential mechanisms that would explain the increase in sidestream smoke toxicity over time, we analyzed unpublished research reports from Philip Morris Co. using the internal tobacco industry documents now available at the University of California San Francisco Legacy Tobacco Documents Library and other Web sites. Unpublished research from Philip Morris Tobacco Company shows that 4-(methylnitrosamino)-I-(3-pyridyl)-1-butanone (NNK), a highly carcinogenic tobacco-specific nitrosamine, can form in sidestream cigarette smoke after it has been released into ambient air. In experiments done between 1983 and 1997, Philip Morris scientists measured the concentration of NNK in sidestream smoke in a sealed stainless steel test chamber at initial particle concentrations of 24 mg/m(3) over the course of 6 to 18 h. They repeatedly showed that airborne NNK concentrations in sidestream cigarette smoke can increase by 50% to 200% per hour during the first 6 h after cigarettes are extinguished. Two experiments done in a real office showed that NNK concentrations increase for the first 2 h after cigarettes are extinguished. If NNK formation also occurs in the lower smoke concentrations observed in real smoking environments, these results suggest that nitrosation of nicotine and/or nicotine breakdown products in aging secondhand smoke is a significant contributor to nitrosamine exposure in humans.

Air Pollutants/analysis, Air Pollution, Indoor/analysis, Carcinogens/analysis/chemistry, Humans, Humidity, Nicotine/chemistry, Nitric Oxide/analysis/chemistry, Nitrogen Dioxide/analysis/chemistry, Nitrosamines/analysis/chemistry, Nitrosation, Temperature, Time Factors, Tobacco Industry, Tobacco Smoke Pollution/analysis

Schick,S. F., Glantz,S.

Center for Tobacco Control Research and Education and the Lung Biology Center, Department of Medicine, University of California San Francisco, Box 0854, San Francisco, CA 94143-1390, USA. sschick@medsfgh.ucsf.edu

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=17684127

2007