Journal Article

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European journal of gastroenterology & hepatology

Eur.J.Gastroenterol.Hepatol.

May

27

5

516

522

JID: 9000874; 0 (Lipoproteins, HDL); ppublish

England

1473-5687; 0954-691X

PMID: 25822860

eng

Journal Article; Research Support, Non-U.S. Gov't; IM

10.1097/MEG.0000000000000334 [doi]

Unknown(0)

25822860

OBJECTIVES: Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) are highly prevalent in the general population, with significant symptom overlap, whereas the interaction between both remains poorly understood. We aim to identify the clinical and psychological factors that contribute toward the overlap of GERD and IBS. PATIENTS AND METHODS: We carried out a case-control study among 806 GERD and 176 IBS patients from a health check-up cohort (n=2604). All participants were evaluated using the Reflux Disease Questionnaire score, the Pittsburgh Sleep Quality Index score, the Taiwanese Depression Questionnaire score, and the State-Trait Anxiety Inventory score. Endoscopic findings were classified according to the Los Angeles classification. IBS was diagnosed on the basis of Rome III criteria, and metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel III definition. RESULTS: Among the study population, 727 individuals had GERD, 97 individuals had IBS, and 79 individuals had a diagnosis of both GERD and IBS (GERD-I). GERD-I patients had more severe GERD symptoms compared with patients with GERD or IBS alone (P

Hsu,C.S., Liu,T.T., Wen,S.H., Wang,C.C., Yi,C.H., Chen,J.H., Lei,W.Y., Orr,W.C., Fabio,P., Chen,C.L.

aDepartment of Internal Medicine, Division of Gastroenterology, Taipei Tzu Chi Hospital bDepartment of Internal Medicine, Division of Gastroenterology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei cSchool of Medicine dDepartment o

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=25822860

2015