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Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Clin.Microbiol.Infect.

Mar

17

3

418

424

LR: 20141120; CI: (c) 2010 The Authors. Clinical Microbiology and Infection (c) 2010; JID: 9516420; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Pyrimidines); 0 (Triazoles); 7XU7A7DROE (Amphotericin B); 9HLM53094I (anidulafungin); JFU09I87TR (Voriconazole

France

1469-0691; 1198-743X

PMID: 20636431

eng

Journal Article; IM

10.1111/j.1469-0691.2010.03302.x [doi]

Unknown(0)

20636431

Candida parapsilosis former groups II and III have recently been established as independent species, named Candida orthopsilosis and Candida metapsilosis, respectively. We investigated the distribution of C. parapsilosis complex species in 122 isolates from blood and other sources in a southern Spain tertiary-care hospital, and we examined the relationship between species, site of isolation and biofilm positivity. We also evaluated the planktonic MICs and sessile MICs (SMICs) of voriconazole, amphotericin B and anidulafungin. One hundred and eleven isolates (91%) were categorized as C. parapsilosis sensu stricto, whereas ten isolates (8.2%) were categorized as C. orthopsilosis and one (0.8%) as C. metapsilosis. Biofilm positivity was observed in 58.5% (65 of 111) of C. parapsilosis sensu stricto isolates vs. 0% (0 of 11) of C. orthopsilosis and C. metapsilosis isolates (p 0.01). There was no difference in biofilm production among C. parapsilosis sensu stricto isolates from blood and other sources. MIC values showed that all isolates were susceptible to voriconazole and amphotericin B, whereas two isolates (1.8%) of C. parapsilosis sensu stricto were non-susceptible to anidulafungin. However, the MIC(9)(0) value of voriconazole was higher (0.125 mg/L) for C. orthopsilosis than for C. parapsilosis sensu stricto (0.03 mg/L). In contrast to planktonic cells, the SMICs show that amphotericin B and anidulafungin are moderately effective against the biofilm of C. parapsilosis sensu stricto, whereas voriconazole is ineffective.

European Society of Clinical Microbiology and Infectious Diseases

de Toro,M., Torres,M.J., Maite,R., Aznar,J.

Service of Microbiology, Hospital Virgen del Rocio, Sevilla, Spain. mdt19772@hotmail.com

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=20636431

2011