Blood nickel and chromium levels in association with smoking and occupational exposure among head and neck cancer patients in Tunisia

Journal Article

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Environmental science and pollution research international

Environ.Sci.Pollut.Res.Int.

Nov

8282

8294

JID: 9441769; 0 (Environmental Pollutants); 0R0008Q3JB (Chromium); 7OV03QG267 (Nickel); CIN: Environ Sci Pollut Res Int. 2013 Nov;20(11):8297. PMID: 23975708; CIN: Environ Sci Pollut Res Int. 2013 Nov;20(11):8295-6. PMID: 23807563; 2012/10/08 [received];

Germany

1614-7499; 0944-1344

PMID: 23625117

eng

Journal Article; Research Support, Non-U.S. Gov't; IM

10.1007/s11356-013-1466-7 [doi]

Unknown(0)

23625117

Chronic exposure to chromium (Cr) and nickel (Ni) has long been recognized as being capable to increase head and neck cancer (HNC) incidence among exposed human populations. This study represents the first biomonitoring of Cr and Ni exposure in Tunisia and focuses on a possible association with HNC risk. The aim of the present study was to evaluate the concentrations of Cr and Ni in the blood of HNC patients and controls. Metals blood levels of 169 HNC patients and 351 controls were determined using a Perkin-Elmer Analyst 800 Atomic Absorption Spectrometer. Mean blood levels of Cr and Ni in HNC cases (52.15 and 111.60 mug/L, respectively) were significantly higher than those of controls (37.04 and 30.50 mug/L, respectively). Cases' blood levels of Cr and Ni were significantly higher than those of controls after controlling for the other risk factors of HNC, including smoking, shisha consumption, occupational exposure, and nearby environment (P

Khlifi,R., Olmedo,P., Gil,F., Feki-Tounsi,M., Chakroun,A., Rebai,A., Hamza-Chaffai,A.

Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia, rimkhlifi@yahoo.fr.

20130428

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=23625117

2013