Journal Article

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Inhalation toxicology

Inhal.Toxicol.

Aug

24

10

667

675

LR: 20151119; GR: R01 CA120142/CA/NCI NIH HHS/United States; GR: R01CA120142/CA/NCI NIH HHS/United States; GR: R03 TW008371/TW/FIC NIH HHS/United States; GR: R03TW008371/TW/FIC NIH HHS/United States; JID: 8910739; 0 (Biomarkers); 0 (Inflammation Mediators

England

1091-7691; 0895-8378

PMID: 22906173

eng

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM

10.3109/08958378.2012.710918 [doi]

Unknown(0)

22906173

CONTEXT: Tobacco smoking represents a global public health threat, claiming approximately 5 million lives a year. Waterpipe tobacco use has become popular particularly among youth in the past decade, buttressed by the perception that the waterpipe "filters" the smoke, rendering it less harmful than cigarette smoke. OBJECTIVE: In this study, we examined the acute exposure of waterpipe smoking on lung inflammation and oxidative stress in mice, and compared that to cigarette smoking. MATERIALS AND METHODS: Mice were divided into three groups; fresh air control, cigarette and waterpipe. Animals were exposed to fresh air, cigarette, or waterpipe smoke using whole body exposure system one hour daily for 7 days. RESULTS: Both cigarette and waterpipe smoke exposure resulted in elevation of total white blood cell count, as well as absolute count of neutrophils, macrophages, and lymphocytes (P 0.01). Both exposures also elevated proinflammatory markers such as TNF-alpha and IL-6 in BALF (P 0.05), and oxidative stress markers including GPx activity in lungs (P 0.05). Moreover, waterpipe smoke increased catalase activity in the lung (P 0.05). However, none of the treatments altered IL-10 levels. DISCUSSION AND CONCLUSION: Results of cigarette smoking confirmed previous finding. Waterpipe results indicate that, similar to cigarettes, exposure to waterpipe tobacco smoke is harmful to the lungs.

Khabour,O.F., Alzoubi,K.H., Bani-Ahmad,M., Dodin,A., Eissenberg,T., Shihadeh,A.

Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan. khabour@just.edu.jo

PMC3752682

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=22906173

2012