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Memorias do Instituto Oswaldo Cruz

Mem.Inst.Oswaldo Cruz

May

107

3

433

436

LR: 20141120; JID: 7502619; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Lipopeptides); 0 (Pyrimidines); 0 (Triazoles); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); 9HLM53094I (anidulafungin); F0XDI6ZL63 (caspofungin); JFU09I87TR (Voriconazole);

Brazil

1678-8060; 0074-0276

PMID: 22510843

eng

Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; IM

S0074-02762012000300022 [pii]

Unknown(0)

22510843

The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations.

Mario,D.A., Denardi,L.B., Bandeira,L.A., Antunes,M.S., Santurio,J.M., Severo,L.C., Alves,S.H.

Departamento de Microbiologia e Parasitologia, Centro de Ciencias da Saude, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. debora_alves6@hotmail.com

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=22510843

2012